Related Experiment Video
Updated: Aug 16, 2026
Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe
Published on: September 17, 2021
Oxidative stress-related molecules as a therapeutic target for inflammatory and allergic diseases
Y Naito1, H Takano, T Yoshikawa
1Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan. ynaito@koto.kpu-m.ac.jp
Abstract:
There is a growing body of evidence that oxidative stress mediated by reactive oxygen species plays an important role in the pathogenesis of various kinds of allergic and non-allergic inflammation. These data suggest that blocking reactive oxygen species should be useful for amelioration of allergic or non-allergic inflammation in the respiratory and intestinal tracts. In addition, the modulation of oxidative stress-related molecules, such as inducible nitric oxide synthase and redox-sensitive transcriptional factors, may be useful for the regulation of these inflammatory responses. In this review, we have summarized the recent advances in the prevention of allergic or non-allergic inflammation, especially the diesel exhaust particle-induced respiratory allergic response and dextran sulfate sodium-induced intestinal inflammation in rodents.
Insights
Oxidative stress from reactive oxygen species drives inflammation. Blocking these species and modulating related molecules can prevent respiratory and intestinal inflammation, offering therapeutic potential.
Area of Science:
- Immunology
- Pathophysiology
- Molecular Biology
Background:
- Oxidative stress, mediated by reactive oxygen species (ROS), is increasingly recognized in the pathogenesis of allergic and non-allergic inflammation.
- ROS play a critical role in inflammatory responses within the respiratory and intestinal tracts.
Purpose of the Study:
- To review recent advances in preventing allergic and non-allergic inflammation.
- To highlight the role of targeting oxidative stress in inflammatory conditions.
- To discuss specific rodent models of inflammation.
Main Methods:
- Review of current scientific literature on oxidative stress and inflammation.
- Analysis of studies focusing on reactive oxygen species (ROS) and their role in inflammation.
- Examination of rodent models, including diesel exhaust particle-induced respiratory allergy and dextran sulfate sodium-induced intestinal inflammation.
Main Results:
- Evidence suggests blocking ROS can ameliorate respiratory and intestinal inflammation.
- Modulating oxidative stress-related molecules, like inducible nitric oxide synthase and redox-sensitive transcriptional factors, aids in regulating inflammatory responses.
- Rodent models demonstrate the efficacy of interventions targeting oxidative stress.
Conclusions:
- Targeting oxidative stress pathways presents a promising strategy for preventing and treating allergic and non-allergic inflammation.
- Further research into ROS modulation could lead to novel therapeutic approaches for inflammatory diseases.
- Understanding the mechanisms of oxidative stress in specific inflammatory models is crucial for developing effective treatments.
