Related Experiment Video
Updated: Aug 16, 2026
10:29
Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
Published on: May 9, 2025
Synthesis and QSAR studies on thiazolidinones as anti-HIV agents
Ravindra K Rawal1, V Raja Solomon, Yenamandra S Prabhakar
1Medicinal Chemistry Division, Central Drug Research Institute, Lucknow 226 001, India.
Combinatorial Chemistry & High Throughput Screening
|August 17, 2005
Abstract:
Selected 4-thiazolidinone have been synthesized and tested as anti-HIV activity. The results of the in vitro tests showed that one of the compounds, 5, inhibited the enzyme at 0.204 microM concentration with minimal toxicity to MT-4 cell. Furthermore, the QSAR studies indicated the role of PMIZ, Ovality and Total energy content of the compounds in rationalizing the activity.
