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Related Experiment Videos

Isocyanates, polyurethane and childhood asthma.

Cheryl A Krone1, Tom D Klingner

  • 1Applied Research Institute, PO Box 1969, Palmerston North, New Zealand. cakrone@u.washington.edu

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|August 17, 2005
PubMed
Summary

Isocyanates in everyday products may contribute to rising asthma rates, particularly in children. Further research is needed on environmental and skin exposure to isocyanates and polyurethanes.

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Area of Science:

  • Environmental Health
  • Immunology
  • Occupational Medicine

Background:

  • Isocyanates are primary causes of occupational asthma, with workplace levels highly regulated.
  • Despite regulations, isocyanate-induced asthma remains prevalent, with dermal exposure gaining attention.
  • The rising asthma prevalence in the general population suggests environmental factors, possibly from consumer products, play a role.

Purpose of the Study:

  • To investigate the potential link between isocyanates in consumer products and the increasing prevalence of asthma.
  • To review evidence for isocyanates and polyurethanes in non-occupational allergy and respiratory diseases.
  • To highlight the need for research into skin exposure and non-occupational asthma.

Main Methods:

  • Review of theoretical, epidemiological, experimental, and clinical evidence.

Related Experiment Videos

  • Examination of isocyanate presence in common polyurethane-containing consumer materials.
  • Analysis of immune system responses to early-life chemical stressors.

    • Main Results:

    • Isocyanates are present in ubiquitous consumer materials like polyurethane foams (furniture, bedding, etc.).
    • Evidence suggests a role for isocyanates and polyurethanes in non-occupational respiratory conditions.
    • Dermal exposure is increasingly recognized as a significant factor in disease etiology.

    Conclusions:

    • Isocyanates in consumer products may contribute to the rise in asthma, especially in children.
    • Urgent research is required to understand the links between isocyanates, polyurethanes, skin exposure, and non-occupational asthma.
    • Environmental and dermal exposure pathways warrant further investigation for asthma prevention.