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Related Experiment Videos

Bacterial internalization in periodontitis.

L Vitkov1, W D Krautgartner, M Hannig

  • 1Department of Operative Dentistry and Periodontology, Saarland University, Germany. lvitkov@yahoo.com

Oral Microbiology and Immunology
|August 17, 2005
PubMed
Summary

Oral bacteria invade periodontitis tissues using fimbriae-mediated adhesion and a zipper mechanism. This bacterial invasion triggers apoptosis in epithelial cells, potentially aiding pathogen clearance.

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Area of Science:

  • Microbiology
  • Cell Biology
  • Periodontology

Background:

  • Bacterial invasion is crucial in periodontitis pathogenesis.
  • The precise mechanisms of bacterial invasion remain unclear.

Purpose of the Study:

  • To investigate the mechanism of bacterial invasion into host epithelial cells in periodontitis.
  • To elucidate the role of bacterial adhesion and internalization in periodontitis.

Main Methods:

  • Analysis of periodontitis pocket epithelium biopsies.
  • Utilized scanning and transmission electron microscopy.
  • Employed ultra-histochemical staining with ruthenium red for glycocalyx visualization.

Main Results:

  • Oral bacteria adhere exclusively via fimbriae-mediated adhesion.

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  • Bacterial internalization occurs through a fimbriae-induced zipper mechanism, characterized by phagocytic cup formation.
  • Apoptosis was frequently observed in phagocytizing epithelial cells.

    • Conclusions:

    • Fimbriae-mediated adhesion is essential for bacterial invasion in periodontitis.
    • The fimbriae-induced zipper mechanism drives bacterial internalization.
    • Epithelial cell apoptosis following invasion may facilitate periodontal pathogen clearance.