Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Snake venoms and hemostasis.

Q Lu1, J M Clemetson, K J Clemetson

  • 1Theodor Kocher Institute, University of Berne, Berne, Switzerland.

Journal of Thrombosis and Haemostasis : JTH
|August 17, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Conservative treatment of complicated oblique crown-root fractures of molars: a report of five representative cases.

Operative dentistry·2013
Same author

Distinct effects of Re- and S-forms of LPS on modulating platelet activation.

Journal of thrombosis and haemostasis : JTH·2013
Same author

Biochemical and functional characterization of a recombinant monomeric factor VIII-Fc fusion protein.

Journal of thrombosis and haemostasis : JTH·2012
Same author

How to assess positive end-expiratory pressure-induced alveolar recruitment?

Minerva anestesiologica·2012
Same author

CD40L demethylation in CD4(+) T cells from women with rheumatoid arthritis.

Clinical immunology (Orlando, Fla.)·2012
Same author

Unique roles of Schistosoma japonicum protein Sj16 to induce IFN-γ and IL-10 producing CD4(+)CD25(+) regulatory T cells in vitro and in vivo.

Parasite immunology·2012
Same journal

RNA Sequencing Indicates Distinct Platelet Transcriptomic Changes in Immune Thrombocytopenia.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

Joint effect of muscle strength and physical inactivity on risk of incident venous thromboembolism: The Tromsø Study.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

The Natural Mutation Arg221aTrp in Human α-Thrombin Abrogates Physiological Na<sup>+</sup> Binding and Preferentially Hinders the Protease Anticoagulant Functions.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

A historical review of the biological, semantic and clinical aspects of aspirin resistance.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

Association between Thrombus Neutrophil Extracellular Traps Content and Ischemic Stroke Recurrence.

Journal of thrombosis and haemostasis : JTH·2026
Same journal

Peptide-Mediated Inhibition of Surface-Initiated Thrombogenesis.

Journal of thrombosis and haemostasis : JTH·2026
See all related articles

Snake venoms contain proteins and peptides that significantly impact blood clotting and platelets. These components can activate or inhibit hemostasis, affecting blood coagulation and causing hemorrhaging.

Area of Science:

  • Biochemistry
  • Toxicology
  • Hematology

Background:

  • Snake venoms are complex biological mixtures.
  • Venom components, including proteins and peptides, profoundly influence hemostasis.
  • They interact with coagulation factors, platelets, and endothelial cells.

Purpose of the Study:

  • To explore the diverse mechanisms by which snake venom components affect hemostasis.
  • To classify snake venom proteins based on their sequence and function.
  • To understand the molecular targets and pathways involved in venom-induced hemostatic dysregulation.

Main Methods:

  • Bioinformatic analysis of venom component sequences.
  • Biochemical assays to study interactions with coagulation factors and platelets.

Related Experiment Videos

  • In vitro and in vivo models to assess hemorrhagic and procoagulant effects.

    • Main Results:

    • Snake venom proteins are classified into families like serine proteases, metalloproteinases, C-type lectins, disintegrins, and phospholipases.
    • These proteins exhibit diverse actions, activating or inhibiting coagulation factors and fibrinolysis.
    • Venom components modulate platelet function by targeting receptors, von Willebrand factor, and signaling pathways, including H2O2 production by L-amino acid oxidases.
    • Enzymatic degradation of basement membrane components leads to hemorrhaging.

    Conclusions:

    • Snake venoms possess a wide array of molecules that precisely target and disrupt the hemostatic system.
    • Understanding these interactions is crucial for developing antivenoms and potential therapeutic agents.
    • Snake venom research provides insights into the complexities of blood coagulation and vascular integrity.