Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Staphylococcus lugdunensis pacemaker-related infection.

Harald Seifert¹, Dirk Oltmanns, Karsten Becker

¹Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany. harald.seifert@uni-koeln.de

Emerging Infectious Diseases

|August 17, 2005

Summary

This study details a rare device-related bloodstream infection caused by Staphylococcus lugdunensis small-colony variants. The infection showed poor response to prolonged antimicrobial therapy, highlighting treatment challenges.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Missed opportunities for antibiotic de-escalation among clinically stable adult patients with bloodstream infection: secondary analysis of a prospective, multicenter study.

International journal of antimicrobial agents·2026

Same author

Comparative evaluation of EUCAST RAST and QuickMIC for rapid antimicrobial susceptibility testing of carbapenem-resistant organisms directly from positive blood cultures.

Microbiology spectrum·2026

Same author

Long-term sequelae after tick-borne encephalitis in Germany: a nationwide claims-based matched cohort study.

Ticks and tick-borne diseases·2026

Same author

Cost-Effectiveness of Alternative Immunization Strategies to Protect Infants Against Respiratory Syncytial Virus in Germany: A Decision Modeling Study.

Infectious diseases and therapy·2026

Same author

All-cause mortality and risk factors for death in patients with Clostridioides difficile infections: a prospective multi-centre cohort study in six German university hospitals, 2016-2020.

The Journal of hospital infection·2026

Same author

Incidence of all-cause and vaccine-preventable, radiologically confirmed community-acquired pneumonia in hospitalised adults in Germany: a multicentre surveillance study (2021-2023).

BMJ open·2026

Area of Science:

Infectious Diseases
Medical Microbiology
Device-Related Infections

Background:

Device-related infections pose significant clinical challenges.
Staphylococcus lugdunensis is an emerging pathogen in device infections.
Small-colony variants (SCVs) of bacteria can exhibit altered virulence and antimicrobial susceptibility.

Observation:

A patient presented with recurrent pacemaker-related bloodstream infections over 10 months.
The infections were caused by Staphylococcus lugdunensis small-colony variants.
Clinical and microbiological assessments indicated a poor response to extended antimicrobial drug therapy.

Findings:

This is the first reported case of a device-related bloodstream infection specifically involving Staphylococcus lugdunensis SCVs.

Related Experiment Videos

The recurrent nature of the infection underscores the difficulty in eradicating SCV infections.

Prolonged antimicrobial therapy was insufficient to resolve the infection.

Implications:

This case highlights the need for increased awareness of Staphylococcus lugdunensis SCVs in device-related infections.
It suggests that standard antimicrobial regimens may be inadequate for treating such infections.
Further research into optimal diagnostic and therapeutic strategies for SCV infections is warranted.