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Antiphospholipid syndrome with anti-prothrombin autoantibodies in a patient with an axial-flow left ventricular
Yasmin Wadia1, Perumal Thiagarajan, Reynolds Delgado
1Department of Cardiovascular Surgery Research, Texas Heart Institute at St Luke's Episcopal Hospital, Houston, 77225, USA. yasminwadia@yahoo.com
Abstract:
Autoantibodies to prothrombin, first described almost 50 years ago, are paradoxically associated with thrombosis. Described is an unusual case of fatal hypercoagulability in a patient with multiple arterial and venous thromboembolic complications despite intense anticoagulation while being bridged to transplantation with a left ventricular assist device. Serum analysis revealed the presence of prothrombin autoantibodies and high titers of anti-nuclear antibodies, and autopsy revealed pulmonary arteriolar vasculitis. These findings suggest an autoimmune basis for the presence of anti-prothrombin antibodies and the hypercoagulable state observed in the present case.
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