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Related Experiment Videos

Spinal oxygenation, blood supply localization, cooling, and function with aortic clamping.

L G Svensson1, E S Crawford, V Patel

  • 1Department of Surgery, Baylor College of Medicine, Houston, Texas 77030.

The Annals of Thoracic Surgery
|July 1, 1992
PubMed
Summary

Spinoplegia may protect the spinal cord during aortic cross-clamping. This study found that spinal cord ischemia occurs in both animals and humans, but spinoplegia reduced motor evoked potential decreases.

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Area of Science:

  • Cardiovascular Surgery
  • Neurosurgery
  • Organ Preservation

Background:

  • Aortic cross-clamping can lead to spinal cord ischemia.
  • Organ preservation techniques are crucial during complex surgeries.
  • Spinoplegia is a potential method to mitigate spinal cord damage.

Purpose of the Study:

  • To investigate the protective effects of spinoplegia on spinal cord oxygen saturation during aortic cross-clamping.
  • To assess spinal cord ischemia in porcine models and human patients.
  • To evaluate the safety and efficacy of intraoperative hydrogen testing for artery localization.

Main Methods:

  • Porcine experiments involving hydrogen localization of spinal cord blood supply, aortic cross-clamping, and spinoplegia infusion.
  • Monitoring of spinal cord oxygen (O2) saturation and spinal motor evoked potentials.

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  • Intraoperative hydrogen testing in human patients to localize arteries during surgery.

    • Main Results:

    • Spinal cord O2 saturation decreased significantly during artery testing and aortic cross-clamping in control animals.
    • Spinoplegia infusion in pigs reduced the decrease in spinal motor evoked potentials.
    • Intraoperative hydrogen testing was safe and accurately localized arteries in patients, though O2 saturation still fell during cross-clamping.

    Conclusions:

    • Spinal cord ischemia is a significant risk associated with aortic cross-clamping in both animal models and human patients.
    • Spinoplegia demonstrates potential in protecting the spinal cord from ischemic injury.
    • Intraoperative hydrogen testing is a safe and effective tool for identifying critical spinal arteries.