Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Jumping translocations in multiple myeloma.

Déborah Jamet1, Youna Marzin, Nathalie Douet-Guilbert

  • 1Laboratoire d'Histologie, Embryologie et Cytogénétique, Faculté de Médecine et des Sciences de la Santé, Université de Bretagne Occidentale, 22 Avenue Camille Desmoulins, Brest cedex F-29285, France.

Cancer Genetics and Cytogenetics
|August 17, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<sup>18</sup>F-FDG PET radiomic analysis to predict outcomes in metastatic melanoma treated with immune checkpoint inhibitors.

Frontiers in immunology·2026
Same author

Chromoanasynthesis.

Methods in molecular biology (Clifton, N.J.)·2025
Same author

Sperm DNA Fragmentation as a Marker of Chromoanagenesis Occurrence During Spermatogenesis.

Methods in molecular biology (Clifton, N.J.)·2025
Same author

MHC class II: a predictor of outcome in melanoma treated with immune checkpoint inhibitors.

Melanoma research·2025
Same author

Zn<sup>2+</sup> triazamacrocyclic chelators with methylpyridine pendant arms for B-cell apoptosis: a structure-activity study.

Dalton transactions (Cambridge, England : 2003)·2025
Same author

Ki67 Immunohistochemical Expression Level ≥70%, Bulky Presentation ≥7.5 cm, Meningeal Lymphomatosis, and Interim PET ΔSUVmax After 4 Treatment Cycles <71% as Parts of a Practical Scoring System to Predict Progression-Free Survival and Overall Survival in Diffuse Large B-Cell Lymphoma.

Frontiers in nuclear medicine·2024

Jumping translocations (JT) are complex chromosomal rearrangements found in advanced multiple myeloma, often involving chromosome 1q. These rearrangements are associated with poor prognosis and may arise from recombination between telomeric and interstitial telomeric sequences.

Area of Science:

  • Cytogenetics
  • Cancer Genetics
  • Molecular Biology

Background:

  • Jumping translocations (JT) are complex chromosomal rearrangements where a donor chromosome segment is nonreciprocally transferred to multiple recipient sites.
  • These rearrangements can occur within different cell lines in a patient (mosaic karyotype) or as extra copies within a single clone.
  • JT involving chromosome 1q have been observed in multiple myeloma, a hematologic malignancy.

Purpose of the Study:

  • To investigate the occurrence and characteristics of jumping translocations (JT) involving chromosome 1q in multiple myeloma patients.
  • To review the literature for additional cases of JT and analyze recipient chromosomes and breakpoint locations.
  • To propose a mechanism for the formation of JT based on sequence homology.

Main Methods:

Related Experiment Videos

  • Karyotyping was performed on 37 patients with chromosome 1 abnormalities to identify cases of JT.
  • A literature review was conducted to identify and analyze previously reported cases of JT.
  • Breakpoint locations on recipient chromosomes and the identity of recipient chromosomes were analyzed.

Main Results:

  • Six out of 37 multiple myeloma patients (16.2%) presented with JT involving chromosome 1q.
  • All six patients had advanced disease and a poor prognosis with short survival.
  • Analysis of 24 additional JT cases from the literature revealed chromosomes 16 and 19 as common recipients, with breakpoints frequently located at pericentromeric and telomeric regions.

Conclusions:

  • Jumping translocations involving chromosome 1q are associated with advanced multiple myeloma and portend a poor prognosis.
  • The frequent involvement of pericentromeric and telomeric regions in JT suggests a mechanism involving illegitimate recombination.
  • It is hypothesized that JT arise through illegitimate recombination between telomere repeat sequences and interstitial telomeric sequences (ITS).