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Permanent Ligation of the Left Anterior Descending Coronary Artery in Mice: A Model of Post-myocardial Infarction Remodelling and Heart Failure
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Left ventricular concentric remodeling is associated with decreased global and regional systolic function: the

Boaz D Rosen1, Thor Edvardsen, Shenghan Lai

  • 1Cardiology Division, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD, USA.

Circulation
|August 17, 2005
PubMed

Insights

Concentric left ventricular remodeling is linked to reduced regional systolic function in asymptomatic individuals. This decline is most notable in the left anterior descending artery region, suggesting early myocardial dysfunction.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Myocardial Mechanics

Background:

  • The progression from compensatory cardiac remodeling to heart failure remains unclear in humans.
  • Investigating factors influencing early myocardial dysfunction is crucial.

Purpose of the Study:

  • To examine the relationship between concentric remodeling and regional left ventricular (LV) function.
  • To understand determinants of incipient myocardial dysfunction in asymptomatic individuals.

Main Methods:

  • Utilized myocardial tagged MRI in 441 asymptomatic participants from the Multi-Ethnic Study of Atherosclerosis (MESA).
  • Analyzed regional myocardial function using peak systolic midwall circumferential strain (Ecc) via Harmonic Phase (HARP) analysis.
  • Assessed concentric remodeling by the ratio of left ventricular mass to end-diastolic volume (M/V ratio).

Main Results:

  • A significant inverse correlation was observed between increasing M/V ratio and peak global Ecc in men (P<0.001).
  • In women, Ecc reduction was significant only between the highest and lowest M/V ratio quintiles (P=0.1).
  • The association of reduced Ecc with higher M/V ratio was prominent in the left anterior descending (LAD) coronary artery territory in both sexes (P<0.001 men, P=0.02 women).

Conclusions:

  • Concentric left ventricular remodeling is associated with diminished regional systolic function in asymptomatic individuals.
  • The observed reduction in regional function, particularly in the LAD territory, may indicate the initial stage of myocardial dysfunction.
  • Findings highlight the potential for early detection of cardiac dysfunction through imaging in remodeling hearts.
Abstract

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