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Related Experiment Videos

Arterial aging: is it an immutable cardiovascular risk factor?

Samer S Najjar1, Angelo Scuteri, Edward G Lakatta

  • 1Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA.

Hypertension (Dallas, Tex. : 1979)
|August 17, 2005
PubMed
Summary
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Aging accelerates arterial changes, increasing cardiovascular disease risk. These vascular alterations are linked to disease progression and can be targeted for intervention, challenging the idea that aging is immutable.

Area of Science:

  • Cardiovascular Biology
  • Vascular Aging
  • Gerontology

Background:

  • Age is the primary risk factor for cardiovascular diseases (CVDs).
  • Mechanistic links between aging and increased CVD risk were previously unclear.
  • Aging impacts large artery structure and function, including stiffness and endothelial function.

Purpose of the Study:

  • To review evidence linking accelerated arterial aging to CVDs.
  • To summarize advances in vascular biology explaining aging-related CVD risks.
  • To highlight potential therapeutic targets for attenuating arterial aging.

Main Methods:

  • Review of existing scientific literature on arterial aging and CVD.
  • Synthesis of evidence on age-associated arterial changes.

Related Experiment Videos

  • Summary of molecular and cellular mechanisms in vascular biology.

    • Main Results:

    • Arterial aging is accelerated in the presence of CVDs.
    • Accelerated arterial aging is a risk factor for adverse cardiovascular outcomes.
    • Biochemical, enzymatic, and cellular alterations in arterial aging are implicated in arterial disease pathogenesis.

    Conclusions:

    • Arterial aging is accelerated by cardiovascular diseases.
    • Targeting vascular alterations in accelerated arterial aging may prevent or retard aging.
    • Aging's cardiovascular risks are potentially modifiable, not merely chronological.