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Hepatitis a in Lebanon: a changing epidemiological pattern.
Robert G Sacy1, Mirna Haddad, Ghassan Baasiri
1St. Georges Hospital, Beirut, Lebanon.
The American Journal of Tropical Medicine and Hygiene
|August 17, 2005
Summary
Hepatitis A virus (HAV) seroprevalence has shifted to older age groups in Lebanon, with 78% of adults over 21 years infected. This highlights the need for HAV vaccination in the national immunization program.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Hepatitis A virus (HAV) infection poses a significant public health concern.
- Understanding seroprevalence patterns is crucial for implementing effective control strategies.
- Previous studies indicated high HAV seroprevalence in younger populations in Lebanon.
Purpose of the Study:
- To determine current hepatitis A virus (HAV) seroprevalence rates in Lebanon.
- To analyze the influence of age, gender, and socioeconomic factors on HAV seroprevalence.
- To compare current seroprevalence data with historical findings and inform vaccination policy.
Main Methods:
- A multicenter study involving 606 participants aged 1 to 30 years.
- Analysis of blood samples for anti-HAV IgG antibodies.
- Statistical analysis to identify factors associated with HAV seroprevalence.
Main Results:
- Overall HAV seroprevalence was significantly higher in older age groups compared to previous studies.
- Seroprevalence was 78% in individuals aged ≥21 years, 28% in the 6-10 years group, and 11% in the 1-5 years group.
- Age was identified as the most significant factor influencing HAV seroprevalence.
Conclusions:
- A notable shift in HAV seroprevalence from younger to older age groups was observed in Lebanon.
- The increased risk of severe HAV infection in adults underscores the importance of vaccination.
- Introduction of HAV vaccination into Lebanon's national immunization schedule is recommended.