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Leukocytoclastic vasculitis: a rare manifestation of propylthiouracil hypersensitivity
Cihangir Erem1, Yusuf Yucel, Ziya Ya
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey. cihangirerem@hotmail.com
Objective:
We report a case of leukocytoclastic vasculitis as a manifestation of propylthiouracil hypersensitivity.
Clinical Presentation And Intervention:
A 66-year-old woman with a history of a toxic adenoma was referred for evaluation of a purpuric rash on the legs and buttocks bilaterally. She was biochemically hyperthyroid. Biopsy of the skin lesions revealed leukocytoclastic vasculitis. Propylthiouracil therapy was discontinued, and methimazole started. The purpuric rash resolved and surgical treatment for toxic adenoma resulted in euthyroid state.
Conclusion:
This report indicated that leukocytoclastic vasculitis should be considered in the differential diagnosis of patients with a vasculitic rash. The discontinuation of the propylthiouracil was associated with disappearance of the lesions.
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