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Two Types of Assays for Detecting Frog Sperm Chemoattraction
Published on: December 27, 2011
HIV-1 chemokine co-receptor CCR5 is expressed on the surface of human spermatozoa
Barbara Muciaccia1, Fabrizio Padula, Loredana Gandini
1Department of Histology and Medical Embryology, University La Sapienza, Rome, Italy.
Abstract:
Viruses adhering to the sperm surface are described in the semen of HIV-1-infected individuals, although viral adhesion mechanisms have yet to be fully understood. We demonstrate, by cytometric analysis and immunofluorescence microscopy, the presence of beta-chemokine receptor 5 (CCR5) on the periacrosomal region of ejaculated spermatozoa. CCR5 expressed on the sperm cell surface may allow sperm to act as virion cellular carriers during the sexual transmission of HIV-1 infection.
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