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Updated: Jul 23, 2026

Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
Published on: August 16, 2016
Peroxisomal matrix protein import: the transient pore model
Ralf Erdmann1, Wolfgang Schliebs
1Institute for Physiological Chemistry, Faculty of Medicine, Ruhr-University Bochum, Germany. ralf.erdmann@rub.de
Abstract:
Peroxisomes import folded, even oligomeric, proteins, which distinguishes the peroxisomal translocation machinery from the well-characterized translocons of other organelles. How proteins are transported across the peroxisomal membrane is unclear. Here, we propose a mechanistic model that conceptually divides the import process into three consecutive steps: the formation of a translocation pore by the import receptor, the ubiquitylation of the import receptors, and pore disassembly/ receptor recycling.
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