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Prevention of binding of rgp120 by anti-HIV active tannins
J L Weaver1, P S Pine, G Dutschman
1Division of Research and Testing, Food and Drug Administration, Washington, DC 20204.
Biochemical Pharmacology
|June 9, 1992
Abstract:
Several tannins with anti-HIV activity have been described previously (Nonaka et al., J Nat Prod 53: 587-595, 1990). We have shown that the tannins chebulinic acid and punicalin were able to block the binding of HIV rgp120 to CD4. These compounds were not toxic to stimulated human peripheral blood lymphocytes at concentrations ten times above their maximal effective concentration.