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Synthesis and pharmacology of some new carbamodithioic acid esters
C Safak1, H Erdogan, A Yesilada
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey.
Arzneimittel-Forschung
|February 1, 1992
Abstract:
In this study 13 new dithiocarbamates were prepared by reacting 3-methyl-6-chloroacetyl-benzoxazolinone with potassium N,N-disubstituted dithiocarbamate derivatives. The structures of the compounds were confirmed by UV, IR, 1H-NMR, mass spectroscopic methods and elementary analysis. The anticholinergic activity was tested on rabbit ileum. With exception of one compound all derivatives exhibited a stronger antihistaminic activity as compared with their anticholinergic action.