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Updated: Aug 16, 2026

Isolation of Atrial Myocytes from Adult Mice
Published on: July 25, 2019
[Cardiovascular effects of human atrial natriuretic peptide during pediatric renal transplantation]
Takashi Terada1, Yohachiro Hirano, Reika Akutsu
1First Department of Anesthesiology, Toho University School of Medicine, Tokyo 143-8541.
Background:
We evaluated the cardiovascular effects of human atrial natriuretic peptide (hANP) in the pediatric recipients undergoing renal transplantation.
Methods:
Anesthesia was maintained by inhalation of nitrous-oxide and isoflurane in oxygen. Intravenous infusion of hANP at a rate of 0.05 microg x kg(-1) x min(-1) was started on the anastomosis of the renal artery after the fresh frozen plasma had been loaded to achieve PCWP above 17 mmHg. We examined cardiovascular changes by using a pulmonary artery catheter and transesophageal echocardiography. The measurements were done before and after 15 minutes of hANP infusion.
Results:
An increase in CI and a reduction in PCWP were significant.
Conclusions:
The low-dose infusion of hANP was useful in pediatric recipients undergoing renal transplantation for the optimal anesthetic care in view of the improvement of cardiovascular functions.
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