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Cancer incidence among Hispanic children in the United States
James D Wilkinson1, Alex Gonzalez, Brad Wohler-Torres
1University of Miami Miller School of Medicine, Florida Cancer Data System, Miami, FL 33101, USA. jwilkins@med.miami.edu
Insights
Overall pediatric cancer incidence is similar between Hispanic and non-Hispanic white children. However, Hispanic children show higher rates of leukemia, Hodgkin
Area of Science:
- Pediatric Oncology
- Epidemiology
- Cancer Research
Background:
- Cancer incidence disparities among racial and ethnic groups are a significant public health concern.
- Hispanic children represent a substantial and growing population in the United States, necessitating specific health outcome research.
Purpose of the Study:
- To conduct a direct comparison of pediatric cancer incidence rates between Hispanic and non-Hispanic white children.
- To analyze cancer incidence in California and Florida, states with large Hispanic child populations, to identify potential disparities.
Main Methods:
- Utilized cross-sectional data from 1988-1998 from the Florida Cancer Data System and California Cancer Registry.
- Included all incident pediatric cancer cases (age < 15 years) categorized as Hispanic or non-Hispanic white.
- Calculated age-standardized incidence rates and compared Hispanic to non-Hispanic white children using standardized incidence ratios (SIRs) with 95% confidence intervals (CIs).
Main Results:
- Overall cancer incidence was similar between Hispanic and non-Hispanic white children (SIR = 1.02; 95% CI: 0.99, 1.05).
- Hispanic children exhibited higher incidences of leukemia (SIR = 1.26), Hodgkin's lymphoma (SIR = 1.29), and germ cell tumors (SIR = 1.62).
- Lower incidences were observed for central nervous system tumors (SIR = 0.72) and sympathetic nervous system tumors (SIR = 0.76) in Hispanic children. Interstate variations noted, with Florida showing higher lymphoma and CNS tumor rates in Hispanic youth, and California higher hepatic tumor rates.
Conclusions:
- While overall cancer incidence is comparable, significant differences in specific tumor types exist between Hispanic and non-Hispanic white children.
- Hispanic ethnicity may act as a confounder for other cancer risk factors, including familial, socioeconomic, and environmental influences.
- Future research should investigate these specific risk factors to understand and address observed disparities in pediatric cancer among Hispanic children.
Objective:
To directly compare cancer incidence among Hispanic children and non-Hispanic white children in California and Florida, two states in the United States of America that include nearly one in three Hispanic children in the country.
Methods:
Cross-sectional data for 1988 through 1998 pertaining to all incident pediatric cancer cases (age < 15 years) with race/ethnicity coded as either Hispanic or non-Hispanic white came from the Florida Cancer Data System database and the California Cancer Registry database. The results were expressed as age-standardized incidence rates, standardized to the world standard million population. Hispanic rates and non-Hispanic white rates were compared using standardized incidence ratios (SIRs) with 95% confidence intervals (95% CIs.).
Results:
The SIR for all cancers for Hispanic children compared to non-Hispanic white children was 1.02 (95% CI: 0.99, 1.05). For selected tumor types, SIRs indicated higher incidences among Hispanic children for leukemia (SIR = 1.26; 95% CI: 1.19, 1.34), Hodgkin's lymphoma (SIR = 1.29; 95% CI: 1.08, 1.54), and germ cell tumors (SIR = 1.62; 95% CI: 1.34, 1.96). There were lower incidences for the Hispanic children for central nervous system tumors (SIR = 0.72; 95% CI: 0.66, 0.78) and for sympathetic nervous system tumors (SIR = 0.76; 95% CI: 0.66, 0.87). In terms of interstate differences, the incidence of lymphoma, central nervous system tumors, sympathetic nervous system tumors, and malignant bone tumors was highest among Hispanic youth in Florida; the incidence of hepatic tumors was highest among Hispanic youth in California.
Conclusions:
While the overall cancer incidence rate among Hispanic children was similar to that for non-Hispanic white children, significant differences for specific tumor types were identified. Since Hispanic ethnicity may be a confounder for other cancer risk factors (e.g., familial, socioeconomic, or environmental), it is recommended that future research into Hispanic pediatric cancer risk investigate these risk factors.
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