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Updated: Jun 19, 2026

Analysis of Oxidative Stress in Zebrafish Embryos
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Published on: July 7, 2014

Oxidative stress in obstructive sleep apnoea.

Anna Svatikova1, Robert Wolk, Lilach O Lerman

  • 1Mayo Clinic College of Medicine, Rochester, MN 55905, USA.

European Heart Journal
|August 18, 2005
PubMed
Summary

Obstructive sleep apnoea (OSA) patients without other health issues do not show elevated oxidative stress or lipid peroxidation. These factors may not be the primary cause of cardiovascular disease in OSA.

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Area of Science:

  • Cardiovascular Health
  • Sleep Medicine
  • Biochemistry

Background:

  • Obstructive sleep apnoea (OSA) is linked to increased cardiovascular disease risk.
  • Sustained oxidative stress is a potential mechanism contributing to this risk.
  • This study investigates oxidative stress markers in OSA patients.

Purpose of the Study:

  • To test if oxidative stress measures are elevated in healthy OSA patients compared to controls.
  • To determine if OSA severity correlates with oxidative stress.
  • To assess the impact of continuous positive airway pressure (CPAP) on oxidative stress.

Main Methods:

  • Measured plasma thiobarbituric acid-reactive substances (TBARS), oxidized LDL (oxLDL), and isoprostanes.
  • Compared 41 moderate-severe OSA males with 35 matched controls.
  • Collected samples before sleep, after untreated OSA, and after CPAP treatment.

Main Results:

  • Plasma levels of oxLDL, TBARS, and isoprostanes were similar between OSA patients and controls.
  • Neither untreated OSA nor CPAP treatment significantly altered oxidative stress markers.
  • No association was found between OSA severity and oxidative stress levels.

Conclusions:

  • Healthy OSA patients without comorbidities do not exhibit increased oxidative stress or lipid peroxidation.
  • Oxidative stress and lipid peroxidation are unlikely to be key mediators of cardiovascular disease in OSA.