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Related Experiment Videos

Interaction between amygdala and neocortical inputs in the perirhinal cortex.

Joe Guillaume Pelletier1, John Apergis-Schoute, Denis Paré

  • 1Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Ave., Newark, New Jersey 07102, USA.

Journal of Neurophysiology
|August 18, 2005
PubMed
Summary

Lateral amygdala stimulation enhances perirhinal cortex excitability but does not facilitate neocortical impulse transfer to the entorhinal cortex. This suggests complex mechanisms regulate information flow between these brain regions.

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neurophysiology

Background:

  • Rhinal cortices are crucial for perception and memory, acting as a key pathway for hippocampal information.
  • Neocortical stimuli activating perirhinal neurons do not effectively activate entorhinal cells, indicating a potential bottleneck in information transfer.

Purpose of the Study:

  • To investigate mechanisms facilitating impulse transfer from the neocortex to the entorhinal cortex.
  • To examine how lateral amygdala (LA) activation influences neuronal excitability in the rhinal cortices.

Main Methods:

  • Electrophysiological recordings in isoflurane-anesthetized animals.
  • Stimulation of the lateral amygdala (LA) and neocortical inputs.
  • Measurement of field potentials and neuronal firing in perirhinal and entorhinal cortices.

Related Experiment Videos

  • Analysis of paired-pulse facilitation (PPF) in the perirhinal cortex.

    • Main Results:

    • LA stimulation activated both perirhinal and entorhinal neurons.
    • Conditioning LA stimuli did not improve neocortical input-driven entorhinal cell activation.
    • Neocortical stimulation induced perirhinal paired-pulse facilitation (PPF), indicating increased perirhinal responsiveness.
    • PPF was linked to a shift in the excitation-inhibition balance within perirhinal neurons.

    Conclusions:

    • While LA activation enhances perirhinal cortex excitability, it does not overcome the barrier to impulse transfer to the entorhinal cortex.
    • Perirhinal paired-pulse facilitation suggests mechanisms that amplify perirhinal processing independently of direct entorhinal input enhancement.
    • Findings highlight the intricate regulation of information flow within the rhinal cortices and their connections.