Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interaction between the immune and central nervous systems.

John H Russell1

  • 1Program in Immunology, Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis, MO 63110, USA. jrussell@wustl.edu

Immunologic Research
|August 18, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genomic selection in western redcedar: from proof of concept to operational application.

The New phytologist·2024
Same author

Histological, chemical and gene expression differences between western redcedar seedlings resistant and susceptible to cedar leaf blight.

Frontiers in plant science·2024
Same author

Genetic architecture of terpene chemistry and growth traits and the impact of inbreeding on these traits in western redcedar (<i>Thuja plicata</i>).

Evolutionary applications·2023
Same author

The western redcedar genome reveals low genetic diversity in a self-compatible conifer.

Genome research·2022
Same author

Genomic selection reveals hidden relatedness and increased breeding efficiency in western redcedar polycross breeding.

Evolutionary applications·2022
Same author

Astrocyte-T cell crosstalk regulates region-specific neuroinflammation.

Glia·2020

Antigen presentation may control immune cell entry into the central nervous system (CNS). Re-evaluating how lymphocytes access the CNS is crucial for understanding neuro-immune interactions.

Area of Science:

  • Neuroimmunology
  • Immunology
  • Central Nervous System (CNS) Research

Background:

  • Immune tolerance traditionally focuses on lymphocyte activation.
  • Emerging evidence suggests anatomical regulation of immune cell access to self-antigens.
  • Tissue-specific addressins (chemokine/chemokine receptor pairs) mediate cell trafficking.

Purpose of the Study:

  • To explore the role of antigen presentation in regulating immune cell entry into the CNS parenchyma.
  • To challenge the dogma that all activated lymphocytes access the CNS.

Main Methods:

  • Review of existing literature on immune cell trafficking and CNS barriers.
  • Hypothetical model proposing antigen presentation by specialized cells within the CNS.

Related Experiment Videos

Main Results:

  • The CNS possesses unique anatomical barriers restricting immune cell movement.
  • Antigen-presenting cells may act as gatekeepers for lymphocyte entry into the CNS parenchyma.

Conclusions:

  • The CNS's unique barriers necessitate a re-evaluation of immune cell access.
  • Antigen presentation could be a critical factor in controlling neuroinflammation and autoimmune diseases within the CNS.