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[Effectiveness of antireflux therapy in asthmatic children with gastroesophageal reflux disease]

Dorin Farcău1, Daniela Dreghiciu, Paraschiva Cherecheş-Panţa

  • 1Clinica Pediatric III - UMF "Iuliu Haţieganu", Cluj-Napoca, România.

Pneumologia (Bucharest, Romania)
|August 19, 2005
PubMed

Insights

Adding gastro-esophageal reflux disease treatment to asthma care significantly improved lung function and reduced asthma attacks in children. This therapy offers a promising approach for managing pediatric asthma with reflux.

Area of Science:

  • Pediatric Pulmonology
  • Gastroenterology
  • Clinical Medicine

Context:

  • Asthma is a common chronic respiratory disease in children.
  • Gastro-esophageal reflux disease (GERD) is increasingly recognized as a potential comorbidity in pediatric asthma.
  • The interplay between GERD and asthma necessitates exploring integrated treatment strategies.

Purpose:

  • To evaluate the efficacy of antireflux therapy in improving clinical and functional parameters in asthmatic children diagnosed with GERD.
  • To assess the impact of combined antireflux and antiasthmatic therapy on asthma exacerbations and pulmonary function.

Summary:

  • A study involving 34 asthmatic children (ages 2.5-17) with diagnosed GERD (via pH-monitoring and endoscopy) received 3 months of antireflux therapy (ranitidine and cisapride) alongside their existing antiasthmatic treatment.
  • Pulmonary function tests (spirometry) were conducted before and after the 3-month treatment period.
  • Results indicated a significant reduction in asthma exacerbation frequency (p=0.016) and notable improvements in FEV1 (p=0.04) and FEV1/FVC ratio (p=0.018) in patients with a positive symptomatic index, and FEV1/FVC (p=0.002) in all children with abnormal GERD.

Impact:

  • Antireflux therapy significantly improves clinical outcomes, including reduced asthma exacerbations, in children with comorbid asthma and GERD.
  • The study demonstrates a significant enhancement in key pulmonary function parameters (FEV1, FEV1/FVC) following integrated treatment.
  • These findings support the addition of antireflux interventions as a valuable component in the comprehensive management of pediatric asthma associated with GERD.

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