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Updated: Aug 16, 2026

Capillary Electrophoresis Mass Spectrometry Approaches for Characterization of the Protein and Metabolite Corona Acquired by Nanomaterials
Published on: October 27, 2020
Utilisation of crown ethers in microemulsion electrokinetic chromatography for the separation of inorganic cations
Helmy A Cook1, Christian W Klampfl, Wolfgang Buchberger
1Institute of Analytical Chemistry, Johannes Kepler University Linz, Altenbergerstr. 69, A-4040 Linz, Austria.
Abstract:
A new method to influence the separation selectivity of inorganic cations in capillary electrophoresis is presented. This method combines the use of certain crown ethers to form complexes with a specific cation (changing its ionic radius/charge ratio and thereby its electrophoretic mobility) with partitioning of the crown ether/analyte complex between an aqueous phase and a pseudo-stationary phase, such as the oil droplet of a microemulsion. Several microemulsions, including uncharged oil droplets and oil droplets with different degrees of surface charge were tested to evaluate their ability to improve the separation of the selected analytes.
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