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Related Experiment Videos

Spitz naevus of the toe.

T Nogita1, M Nagayama, M Kawashima

  • 1Department of Dermatology, Tokyo Women's Medical College, Japan.

The British Journal of Dermatology
|May 1, 1992
PubMed
Summary

A rare Spitz nevus, an unusual skin tumor, was found on a Japanese woman's toe. Differentiating it from melanoma involved analyzing melanin and DNA patterns.

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Area of Science:

  • Dermatopathology
  • Oncology
  • Histology

Background:

  • Spitz nevi are typically benign skin tumors often found on the face and extremities.
  • Epithelioid cell tumors require careful histological evaluation to distinguish benign from malignant lesions.
  • Melanoma diagnosis relies on specific cellular and molecular markers.

Observation:

  • A 68-year-old Japanese woman presented with a brownish macule and papules on her left fourth toe.
  • Histological examination revealed an intradermal epithelioid cell tumor characterized by bizarre giant cells.
  • The tumor's epithelioid cells contained abundant melanin in the upper portion.

Findings:

  • The lesion was identified as an intradermal epithelioid cell tumor.
  • Low levels of 5-S-cysteinyldopa and a diploid DNA histogram aided in differentiating the lesion from malignant melanoma.
  • The toe location was considered exceptional for a Spitz nevus.

Implications:

  • This case highlights the importance of thorough histological and molecular analysis for accurate diagnosis of skin lesions.
  • Recognizing unusual presentations of Spitz nevi is crucial for appropriate patient management.
  • Further research into the specific characteristics of Spitz nevi in atypical locations may be warranted.

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