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Biochemical Purification and Proteomic Characterization of Amyloid Fibril Cores from the Brain
Published on: April 28, 2022
[Stress proteins in Alzheimer's disease]
Abstract:
Alzheimer's disease (AD) progression can be restricted by brain self-defense systems for a long time since the onset. Among these an exclusive role is played by the system of stress proteins, or heat shock proteins. In AD, stress proteins play primarily a neuroprotective role, which is realized through at least 7 mechanisms: 1) restriction of apoptosis; 2) restriction of NO overproduction; 3) disaggregation of extracellular Abeta aggregates; 4) acceleration of Abeta elimination from intercellular space; 5) restriction of tau-protein hyperphosphorylation; 6) protection of neurons from glutamate toxicity; 7) restriction of intracellular Abeta cytotoxicity. Results of studies on protective effects of heat shock proteins in AD allow creation of a new trend in the field of the treatment, related with developing methods of activation of stress protein self-defense system in order to restrict neurodegenerative disorders. The given review presents theoretical and experimental prerequisites for such an approach, and substantiates its possible efficiency.
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