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Related Experiment Videos

Cocaine-induced brainstem seizures and behavior.

X B Qian1, O J Andy, C Dearman

  • 1Department of Neurosurgery, University of Mississippi Medical Center, Jackson 39216.

Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society
|April 1, 1992
PubMed
Summary

Electrical stimulation and cocaine induce abnormal behaviors in rats by activating brainstem discharges. These findings suggest the brainstem generates pathological activity affecting sensory and motor functions.

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Area of Science:

  • Neuroscience
  • Behavioral Neuroscience

Background:

  • The brainstem plays a crucial role in regulating sensory and motor functions.
  • Abnormal brainstem activity can lead to various neurological and behavioral deficits.

Purpose of the Study:

  • To investigate the induction of abnormal sensory/motor behaviors via brainstem perturbation in rats.
  • To examine the role of cocaine in exacerbating these behaviors.

Main Methods:

  • Adult WKY rats were subjected to mechanical (electrode implants) and DC electrical stimulation of the brainstem.
  • Cocaine was administered acutely (40 mg/kg) and chronically (20 mg/kg twice daily for 3 days).
  • Abnormal behaviors and electrophysiological changes (power frequency spectra) were recorded.

Main Results:

Related Experiment Videos

  • Both electrical stimulation and cocaine induced a range of abnormal behaviors including yawning, hyperactivity, and hypersensitivity.
  • Cocaine significantly increased abnormal behaviors, particularly in electrically stimulated rats.
  • Shifts in brainstem discharge power spectra correlated with behavioral states and tactile stimulation.

Conclusions:

  • The brainstem can generate and propagate pathological discharges, elicited by mechanical and electrical stimuli.
  • Cocaine activates this brainstem discharge system, leading to abnormal behaviors.
  • These findings suggest potential involvement of dopaminergic and serotonergic pathways in cognitive functions.