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Related Concept Videos

Schizophrenia01:17

Schizophrenia

856
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
856
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

551
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
551
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

516
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
516
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

528
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
528
Positive Symptoms Schizophrenia: Hallucinations and Delusions01:26

Positive Symptoms Schizophrenia: Hallucinations and Delusions

538
Schizophrenia is a complex psychiatric disorder characterized by a range of symptoms that significantly impact cognition, behavior, and emotional regulation. Among these, the positive symptoms stand out as they involve the addition or exaggeration of normal mental functions, deviating markedly from typical behavior and perception. Hallucinations and delusions are prominent positive symptoms, each profoundly affecting the individual's experience of reality.
Hallucinations
Hallucinations in...
538
Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

602
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
602

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Related Experiment Video

Updated: Jan 27, 2026

Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram
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Neurologic comorbidities in schizophrenia.

Henry A Nasrallah1

  • 1Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, USA. henry.nasrallah@uc.edu

The Journal of Clinical Psychiatry
|August 19, 2005
PubMed
Summary

Schizophrenia involves brain abnormalities, including reduced brain volumes and early neurologic signs often missed. Recognizing these can lead to earlier diagnosis and better outcomes.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Radiology

Background:

  • Schizophrenia pathophysiology is linked to brain abnormalities.
  • Structural and functional neuroimaging reveals reduced brain, frontal lobe, and hippocampal volumes in patients.
  • Neurologic disorders often precede schizophrenia onset and may be predictive.

Purpose of the Study:

  • Review structural and functional brain imaging abnormalities in schizophrenia.
  • Discuss co-occurring neurologic disorders in schizophrenia patients.
  • Examine the impact of atypical antipsychotic treatment on neurologic abnormalities.

Main Methods:

  • Review of structural and functional neuroimaging studies in schizophrenia.
  • Analysis of neurologic disorders associated with schizophrenia.

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  • Discussion of the effects of atypical antipsychotics on brain structure.

    • Main Results:

    • Schizophrenia is associated with widespread brain volume reductions.
    • Pre-schizophrenia neurologic deficits are frequently overlooked but potentially predictive.
    • Antipsychotic treatment may influence observed brain changes.

    Conclusions:

    • Increased awareness of neurologic and imaging abnormalities is crucial.
    • Complete neurologic assessment before treatment is vital for early schizophrenia detection.
    • Early identification and intervention can improve long-term outcomes for schizophrenia.