Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Absolute and Local Extreme Values01:22

Absolute and Local Extreme Values

86
The highest and lowest values of a function, relative to a reference axis, are known as extreme values. These include absolute maximum and absolute minimum values, which represent the highest and lowest points the function reaches across its entire domain. Within a restricted portion of the function, the highest and lowest values are referred to as local maximum and local minimum values, respectively.Periodic functions, such as sine and cosine, show extreme values at infinitely many points due...
86
Cancer02:18

Cancer

54.4K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
54.4K
Local Attraction01:22

Local Attraction

389
Local attraction refers to disturbances in compass readings caused by magnetic influences from nearby objects such as metal fences, buried pipes, vehicles, buildings, power lines, or natural iron ore deposits. Small items like wristwatches, steel tools, or belt buckles can also interfere with the compass by creating local magnetic fields that distort the Earth's natural magnetic field. These distortions lead to inaccurate readings, posing navigation and land surveying challenges.Local...
389
Local Anesthetics: Pharmacokinetics01:13

Local Anesthetics: Pharmacokinetics

1.2K
The potency and duration of action of local anesthetics (LAs) are determined by their pharmacokinetics. Pharmacokinetics describes how LAs are absorbed, distributed, metabolized, and eliminated from the body. When administered to the vascular tissues, LAs are quickly absorbed and enter the systemic circulation, reducing their localized effects. Adding vasoconstrictors such as epinephrine to LAs reduces their absorption into the systemic circulation, making them clinically effective. The...
1.2K
Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

815
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
815
What is Cancer?02:12

What is Cancer?

14.5K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
14.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

External Beam Radiation Therapy With or Without Brachytherapy Boost in Men With Very-High-Risk Prostate Cancer: A Large Multicenter International Consortium Analysis.

International journal of radiation oncology, biology, physics·2022
Same author

Coronary intravascular brachytherapy for in-stent restenosis: A review of the contemporary literature.

Brachytherapy·2022
Same author

Interplay Between Duration of Androgen Deprivation Therapy and External Beam Radiotherapy With or Without a Brachytherapy Boost for Optimal Treatment of High-risk Prostate Cancer: A Patient-Level Data Analysis of 3 Cohorts.

JAMA oncology·2022
Same author

Performance of a Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography-Derived Risk-Stratification Tool for High-risk and Very High-risk Prostate Cancer.

JAMA network open·2021
Same author

<sup>125</sup>I Interstitial brachytherapy with or without androgen deprivation therapy among unfavorable-intermediate and high-risk prostate cancer.

Brachytherapy·2021
Same author

Comparison of Multimodal Therapies and Outcomes Among Patients With High-Risk Prostate Cancer With Adverse Clinicopathologic Features.

JAMA network open·2021

Related Experiment Video

Updated: Feb 10, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

11.3K

Prostate brachytherapy for localized prostate cancer.

Jay P Ciezki1

  • 1Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. ciezkij@ccf.org

Current Treatment Options in Oncology
|August 19, 2005
PubMed
Summary

Prostate cancer (CaP) is often diagnosed early, with similar cure rates across treatments. Prostate brachytherapy (PI) offers the least long-term toxicity, making it a preferred choice for patients.

Area of Science:

  • Oncology
  • Urology

Background:

  • Prostate cancer (CaP) is the second most common cancer in men.
  • Early detection via prostate-specific antigen (PSA) screening has improved cure rates.
  • Current data do not establish superiority of one treatment modality over another.

Purpose of the Study:

  • To evaluate treatment modalities for prostate cancer.
  • To compare efficacy and toxicity of different prostate cancer treatments.
  • To guide patient counseling based on treatment outcomes.

Main Methods:

  • Comparative analysis of prostate cancer treatment modalities.
  • Review of cure rates and toxicity profiles for low- and intermediate-risk patients.
  • Evidence-based algorithm for treatment selection.

More Related Videos

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

14.6K
An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

35.9K

Related Experiment Videos

Last Updated: Feb 10, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

11.3K
Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

14.6K
An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

35.9K

Main Results:

  • Expected cure rates are ~90% for low-risk and ~80% for intermediate-risk CaP.
  • All modalities exhibit similar acute toxicity.
  • Prostate brachytherapy (PI) demonstrates the lowest long-term toxicity compared to external beam radiotherapy and radical prostatectomy.

Conclusions:

  • Patient counseling for CaP should prioritize treatment toxicity over efficacy.
  • Prostate brachytherapy (PI) is increasingly favored due to its favorable long-term toxicity profile.
  • An evidence-based approach to treatment selection is recommended for prostate cancer patients.