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Related Experiment Videos

Cross state-dependent retrieval between histamine and lithium.

Mohammad-Reza Zarrindast1, Soheila Fazli-Tabaei, Azita Khalilzadeh

  • 1Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Iran. zarinmr@ams.ac.ir

Physiology & Behavior
|August 19, 2005
PubMed
Summary

Histamine and lithium can induce state-dependent memory retrieval in mice. A cross-state-dependency between these substances suggests a shared pathway, potentially involving the inositol pathway.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Behavioral Science

Background:

  • State-dependent retrieval (StD) is a phenomenon where memory recall is facilitated when the internal state during retrieval matches the state during learning.
  • Histamine and lithium are known neuromodulators with potential roles in memory processes.

Purpose of the Study:

  • To investigate the state-dependent retrieval (StD) effects of histamine and lithium on a passive avoidance task in mice.
  • To examine the interactions and potential cross-StD between histamine and lithium in memory retrieval.

Main Methods:

  • Mice were administered intracerebroventricular (i.c.v.) injections of histamine or intraperitoneal injections of lithium at pre-training or pre-test phases.
  • Passive avoidance tasks were used to assess memory retrieval 24 hours after training.

Related Experiment Videos

  • Pharmacological agents, including H1 (pyrilamine) and H2 (ranitidine) blockers, were used to probe the mechanisms of histamine-induced StD.

    • Main Results:

    • Both histamine and lithium impaired memory retrieval when administered pre-training or pre-test.
    • Pre-test administration of histamine restored retrieval impaired by pre-training histamine, an effect blocked by the H1 antagonist pyrilamine.
    • Pre-test administration of histamine or lithium restored retrieval impaired by pre-training of the respective substance, indicating a cross-StD.
    • The restoration of retrieval by pre-test lithium was not affected by pyrilamine or ranitidine.

    Conclusions:

    • Histamine and lithium can independently induce state-dependent memory retrieval in mice.
    • A cross-state-dependency exists between histamine and lithium, suggesting a shared underlying neurochemical pathway.
    • This cross-StD may be mediated through the inositol signaling pathway.