Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Is inflammation important in early PPMS? a longitudinal MRI study.

G T Ingle1, J Sastre-Garriga, D H Miller

  • 1Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK.

Journal of Neurology, Neurosurgery, and Psychiatry
|August 19, 2005
PubMed
Summary

Inflammation, indicated by contrast enhancement on MRI, is present in early primary progressive multiple sclerosis (PPMS). This early inflammation correlates with increased disability and MRI-detected disease burden in PPMS patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Anti-HBs Immune Complex Levels: A Novel Marker of Hepatitis Flare Following Nucleos(t)ide Analog Withdrawal in HBeAg-negative Chronic Hepatitis B.

The Journal of infectious diseases·2025
Same author

Balancing Efficiency and Accuracy in Hepatitis C Rapid Antibody Testing: Insights From a Cluster Randomised Crossover Trial.

Journal of viral hepatitis·2025
Same author

Editorial: Ultralow HBsAg Levels and the Prediction of Cure in Chronic Hepatitis B.

Alimentary pharmacology & therapeutics·2025
Same author

New insights into the effects of ethylene on ABA catabolism, sweetening and dormancy in stored potato tubers.

Postharvest biology and technology·2021
Same author

Direct Measurement of Single-Molecule Ligand-Receptor Interactions.

The journal of physical chemistry. B·2020
Same author

Prevalence of baseline HCV NS5A resistance associated substitutions in genotype 1a, 1b and 3 infection in Australia.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2019

Area of Science:

  • Neurology
  • Radiology
  • Immunology

Background:

  • Previous MRI studies in primary progressive multiple sclerosis (PPMS) suggest less inflammation compared to relapsing-remitting multiple sclerosis (RRMS).
  • The role of early inflammation in PPMS pathogenesis remains unclear due to limited study of earliest clinical stages.

Purpose of the Study:

  • To investigate the presence, characteristics, and clinical implications of inflammation in early PPMS.
  • To determine if an early inflammatory phase exists in PPMS.

Main Methods:

  • 45 early PPMS patients (mean disease duration 3.3 years) underwent triple-dose gadolinium-enhanced MRI, Expanded Disability Status Scale (EDSS), and Multiple Sclerosis Functional Composite (MSFC) assessments.
  • Serial MRIs were performed at 1, 2, and 6 months in subsets of patients to track lesion evolution.

Related Experiment Videos

Main Results:

  • Enhancing brain lesions were observed in 42% of patients at baseline; enhancing spinal cord lesions were rare (7%).
  • Most enhancing lesions (85%) resolved within one month.
  • Patients with enhancing lesions exhibited significantly greater clinical disability (EDSS, MSFC) and higher MRI burden (T2/T1 lesion load, reduced brain volume).
  • Enhancement persisted at 6 months in 32% of patients, exclusively in those who enhanced at baseline.

Conclusions:

  • Contrast enhancement indicates active inflammation in a subset of early PPMS cases.
  • Early PPMS inflammation is associated with increased clinical disability and greater overall disease burden on MRI.