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Tolterodine-induced hyponatraemia.

Jatinder K Juss1, Ajish K J Radhamma, Duncan R Forsyth

  • 1Department of Medicine for the Elderly, Addenbrooke's Hospital, Cambridge University Hospitals Foundation Trust, Hills Road, Cambridge CB2 2QQ, UK.

Age and Ageing
|August 19, 2005
PubMed
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Elderly individuals often face challenges with electrolyte balance. This case report highlights hyponatremia, a common issue in older adults, linked to the drug tolterodine.

Area of Science:

  • Geriatric Medicine
  • Nephrology
  • Clinical Pharmacology

Background:

  • Electrolyte abnormalities are common and challenging in older adults due to impaired thirst, renal function, and hormonal regulation.
  • Ageing-related homeostatic changes are often compounded by chronic diseases, malnutrition, and medications.
  • Hyponatremia affects approximately 7% of healthy elderly individuals and can be asymptomatic, discovered during investigations for other ailments.

Observation:

  • Drug-induced hyponatraemia is prevalent in the elderly, commonly associated with diuretics and SSRI/SNRI antidepressants.
  • This case report identifies tolterodine as a potential cause of drug-induced hyponatraemia.
  • The patient presented with hyponatraemia, prompting an investigation into medication side effects.

Findings:

Related Experiment Videos

  • Tolterodine, an anticholinergic medication, was identified as the causative agent for hyponatraemia in this patient.
  • This represents the first documented instance of tolterodine-induced hyponatraemia.
  • The findings underscore the need for vigilance regarding drug-induced electrolyte disturbances in geriatric populations.

Implications:

  • Clinicians should consider tolterodine when evaluating hyponatraemia in older patients.
  • This case expands the list of medications known to cause hyponatraemia.
  • Further research may be warranted to explore the mechanism and prevalence of tolterodine-induced hyponatraemia.