Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mast cell beta2-adrenoceptors.

Linda J Kay1, Peter T Peachell

  • 1Molecular Pharmacology, University of Sheffield, The Royal Hallamshire Hospital, Sheffield, UK.

Chemical Immunology and Allergy
|August 19, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-Time In Vivo Human Skin Testing Using a Handheld Fourier Transform Infrared Spectrometer with a Three-Bounce Two-Pass Attenuated Total Reflection Interface.

Applied spectroscopy·2024
Same author

Maintenance of an Acidic Skin Surface with a Novel Zinc Lactobionate Emollient Preparation Improves Skin Barrier Function in Patients with Atopic Dermatitis.

Dermatology and therapy·2024
Same author

Different types of emollient cream exhibit diverse physiological effects on the skin barrier in adults with atopic dermatitis.

Clinical and experimental dermatology·2022
Same author

Enhancement of stratum corneum lipid structure improves skin barrier function and protects against irritation in adults with dry, eczema-prone skin.

The British journal of dermatology·2021
Same author

Response to: Letter to the Editor Regarding "An Investigation of the Skin Barrier Restoring Effects of a Cream and Lotion Containing Ceramides in a Multi-Vesicular Emulsion in People with Dry, Eczema-Prone, Skin: The RESTORE Study Phase 1".

Dermatology and therapy·2021
Same author

Role of Tyrosine Kinases in IgE-Mediated Signal Transduction in Human Lung Mast Cells and Basophils.

International archives of allergy and immunology·2021
Same journal

Educational programmes in food allergy.

Chemical immunology and allergy·2015
Same journal

Prevention of food allergy.

Chemical immunology and allergy·2015
Same journal

The effects of food allergy on quality of life.

Chemical immunology and allergy·2015
Same journal

Worldwide food allergy labeling and detection of allergens in processed foods.

Chemical immunology and allergy·2015
Same journal

Food allergy: psychosocial impact and public policy implications.

Chemical immunology and allergy·2015
Same journal

Nutritional aspects and diets in food allergy.

Chemical immunology and allergy·2015
See all related articles

Beta2-adrenoceptor agonists stabilize human lung mast cells, inhibiting asthma mediators. Their effectiveness and tolerance vary, potentially influenced by receptor density and genetic factors.

Area of Science:

  • Immunology
  • Pharmacology
  • Respiratory Medicine

Background:

  • Human lung mast cells are key in asthma pathogenesis, releasing mediators that cause bronchoconstriction and inflammation.
  • Allergen activation triggers mast cell mediator release, contributing significantly to asthma symptoms.

Purpose of the Study:

  • To investigate the role of beta2-adrenoceptor agonists in inhibiting mast cell mediator release.
  • To explore factors influencing the efficacy and tolerance of beta2-adrenoceptor agonists on mast cells.

Main Methods:

  • Studied the inhibitory effects of various beta2-adrenoceptor agonists on human lung mast cells.
  • Assessed mast cell mediator release and the development of tolerance to agonist treatment.

Main Results:

Related Experiment Videos

  • Beta2-adrenoceptor agonists effectively inhibit mediator release from human lung mast cells.
  • Agonist efficacy and tolerance induction varied, influenced by receptor density and potentially genetic polymorphisms.
  • Tolerance did not correlate with beta2-adrenoceptor density loss.

Conclusions:

  • Beta2-adrenoceptor agonists are important in managing asthma by stabilizing mast cells.
  • Individual responses to these drugs may be modulated by receptor characteristics and genetics.