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Pharyngeal infection with Neisseria gonorrhoeae
Abstract:
During 1978, 156 patients were treated for pharyngeal infection with Neisseria gonorrhoeae; 115 (74%) returned for a posttreatment culture. Aqueous procaine penicillin G (4.8 X 10(6) units) given im with (19 patients) or without (64 patients) orally administered ampicillin for four days was successful therapy in 86% of instances. All seven patients who received tetracycline hydrochloride orally for five days had negative posttreatment cultures, as did nine of 12 patients who received 2.0 g (four patients) or 4.0 g (eight patients) of spectinomycin hydrochloride, im. Concurrent anogenital infection with N. gonorrhoeae was documented for about 60% of the patients, and, with one exception, was eradicated by these treatment schedules.
Insights
Penicillin G, with or without ampicillin, effectively treated pharyngeal gonorrhea in 86% of patients. Tetracycline and spectinomycin also showed high success rates for this common sexually transmitted infection.
Area of Science:
- Infectious Diseases
- Microbiology
- Public Health
Background:
- Pharyngeal gonorrhea, caused by Neisseria gonorrhoeae, presents a significant public health challenge.
- Effective treatment regimens are crucial for eradicating the infection and preventing transmission.
Purpose of the Study:
- To evaluate the efficacy of different antibiotic treatments for pharyngeal gonorrhea.
- To assess the success rates of penicillin G, ampicillin, tetracycline, and spectinomycin in treating this infection.
Main Methods:
- A cohort of 156 patients diagnosed with pharyngeal gonorrhea in 1978 were treated with various antibiotic regimens.
- Posttreatment cultures were obtained from 115 (74%) patients to assess treatment outcomes.
- Treatment groups included aqueous procaine penicillin G with or without oral ampicillin, oral tetracycline hydrochloride, and intramuscular spectinomycin hydrochloride.
Main Results:
- Aqueous procaine penicillin G, with or without oral ampicillin, achieved an 86% success rate in treating pharyngeal gonorrhea.
- Tetracycline hydrochloride administered orally for five days resulted in negative posttreatment cultures for all seven patients.
- Spectinomycin hydrochloride showed high efficacy, with 9 out of 12 patients clearing the infection.
Conclusions:
- Penicillin G-based therapies are effective for pharyngeal gonorrhea.
- Tetracycline and spectinomycin represent viable alternative treatment options.
- Concurrent anogenital gonorrhea infections were largely eradicated by the studied treatment schedules.