[Side effects of cellular and acellular DPT vaccine in children aged from 3 months to 5 years]

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A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
11:17

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Published on: August 11, 2018

Smajil Durmisević1, Jasminka Durmisevict-Serdarević

  • 1Kantonalni zavod zajavno zdravstvo, Zenica. smaildur@bih.net.ba

Medicinski Pregled
|August 20, 2005
PubMed

Insights

Acellular DTPa vaccines show significantly fewer local and systemic reactions in infants compared to whole-cell DTPw vaccines. This study indicates DTPa vaccines are safer for infant immunization, with reduced adverse events like fever and crying.

Area of Science:

  • Pediatric immunology
  • Vaccinology
  • Public health

Context:

  • Postvaccination reactions are a concern in infant immunization schedules.
  • Comparing the safety profiles of different DTP vaccine formulations is crucial for public health recommendations.

Purpose:

  • To compare the incidence of local and systemic adverse reactions between acellular (DTPa) and whole-cell (DTPw) pertussis vaccines in children aged three months to five years.

Summary:

  • A study of 940 children found DTPa vaccines resulted in significantly fewer adverse reactions (1.64%) compared to DTPw vaccines (5.4%).
  • Specific reactions like fever over 38.5°C, vomiting, swelling, redness, prolonged crying, convulsions, and collapse were less frequent with DTPa.
  • Convulsions and collapse were not observed in infants receiving DTPa, highlighting its improved safety profile.

Impact:

  • The findings support the use of acellular DTPa vaccines as a safer alternative for infant immunization.
  • Reduced adverse reactions can improve vaccine acceptance and adherence to immunization schedules.
  • This research contributes to evidence-based guidelines for pediatric vaccination strategies.
Abstract

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