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Distribution and determinants of coronary artery disease in an urban Pakistani setting

Sunita Dodani1, David D MacLean, Ronald E LaPorte

  • 1Department of Epidemiology; University of Pittsburgh, Pittsburgh, PA 15101, USA. sud0@pitt.edu

Ethnicity & Disease
|August 20, 2005
PubMed

Insights

Coronary artery disease (CAD) in Pakistan is strongly linked to age over 40, diabetes, and family history. Further research into unique Pakistani characteristics and high-risk groups is recommended.

Area of Science:

  • Cardiology
  • Public Health
  • Epidemiology

Background:

  • Coronary artery disease (CAD) poses a significant health burden globally.
  • Understanding the distribution and risk factors of CAD in specific populations, such as Pakistanis, is crucial for targeted interventions.

Purpose of the Study:

  • To assess the prevalence of CAD.
  • To determine the association between major biological risk factors and CAD in Pakistani adults presenting at a tertiary care hospital in Karachi.

Main Methods:

  • A cross-sectional epidemiologic study was conducted.
  • 600 adult patients visiting family practice clinics were included.
  • Associations between CAD and risk factors (age, BMI, hypertension, diabetes, cholesterol, family history, etc.) were analyzed.

Main Results:

  • Univariate analysis identified age (>=40 years), obesity (BMI >=29.9 kg/m2), diabetes, high cholesterol, and family history of ischemic heart disease (IHD) as associated with CAD.
  • Multivariate analysis confirmed age (>=40 years), diabetes, and a positive family history of IHD as strongly related to CAD.

Conclusions:

  • Major risk factors show a strong association with CAD in this Pakistani cohort.
  • Further in-depth studies focusing on the unique characteristics of Pakistanis and high-risk groups are warranted.
Abstract

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