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Hyperglycaemia and mortality of diabetic patients with candidaemia

M S Bader1, D Hinthorn, S M Lai

  • 1Division of Infectious Diseases, Department of Preventive Medicine, University of Kansas Medical Center, KS, USA. msbader1@hotmail.com

Diabetic Medicine : a Journal of the British Diabetic Association
|August 20, 2005
PubMed

Insights

Severe hyperglycemia in diabetic patients with candidaemia significantly increases in-hospital mortality risk. This finding highlights the importance of glycemic control in managing this vulnerable patient population.

Area of Science:

  • Medical research
  • Infectious diseases
  • Endocrinology

Background:

  • Candidaemia is a serious fungal infection, particularly in diabetic patients.
  • Hyperglycaemia is common in diabetic patients and may affect infection outcomes.

Purpose of the Study:

  • To investigate the association between the degree of hyperglycaemia and in-hospital mortality in diabetic patients diagnosed with candidaemia.

Main Methods:

  • A retrospective cohort study included 87 diabetic patients with candidaemia.
  • Patients were categorized into moderate (<13.9 mmol/l) and severe (>=13.9 mmol/l) hyperglycaemia groups based on mean blood glucose 7 days post-candidaemia.
  • Stepwise logistic regression analysis was used to identify mortality predictors.

Main Results:

  • Overall in-hospital mortality was 39.1% (34/87).
  • Patients with severe hyperglycaemia had a significantly higher mortality rate (69.2%) compared to those with moderate hyperglycaemia (33.8%).
  • Independent predictors of death included high Apache II score, severe hyperglycaemia (mean blood glucose >= 13.9 mmol/l), and mechanical ventilation.

Conclusions:

  • Severe hyperglycaemia is a significant independent predictor of increased in-hospital mortality in diabetic patients with candidaemia.
  • Effective glycemic management is crucial for improving outcomes in these patients.
Abstract

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