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Semi-Automatic Graphical Tool for Measuring Coronary Artery Spatially Weighted Calcium Score from Gated Cardiac Computed Tomography Images
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Role of sevelamer hydrochloride in the coronary artery calcification score

Yoshinari Tsuruta1, Kana Kaneshiro, Yukio Narita

  • 1Department of Nephrology, Meiyo Clinic, Hemodialysis Center, Aichi, Japan. ytsuruta@meiyokai.or.jp

Therapeutic Apheresis and Dialysis : Official Peer-Reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
|August 20, 2005
PubMed

Insights

Coronary artery calcification scores increase in hemodialysis patients. Higher sevelamer hydrochloride dosage and triglycerides correlate with increased calcification, suggesting a link to calcium and phosphate metabolism in these patients.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Biochemistry

Background:

  • Coronary artery calcification score (CACS) is elevated in hemodialysis (HD) patients compared to non-HD individuals across multiple age groups.
  • Understanding factors influencing CACS progression in HD patients is crucial for cardiovascular risk management.

Purpose of the Study:

  • To investigate the relationship between the rate of change in CACS (alphaCACS) and factors related to calcium and phosphate metabolism in HD patients.
  • To identify specific parameters correlating with CACS progression in this population.

Main Methods:

  • A longitudinal study involving 144 HD outpatients, measuring CACS twice over approximately 12 months (2003-2004).
  • Vigilant management of vitamin D and phosphate binders (sevelamer hydrochloride, calcium carbonate) to control serum calcium and phosphate levels.
  • Analysis of various parameters including medication dosages, serum calcium, phosphate, alkaline phosphatase, HS-PTH, total protein, albumin, total cholesterol, and triglycerides (TG).

Main Results:

  • Regression analysis revealed a significant correlation between the total sevelamer hydrochloride dosage, triglyceride levels, and the change in CACS (alphaCACS).
  • The study identified key metabolic and treatment-related factors associated with CACS progression in hemodialysis patients.

Conclusions:

  • The findings suggest that sevelamer hydrochloride dosage and triglyceride levels are associated with the progression of coronary artery calcification in hemodialysis patients.
  • Further research is warranted to explore the impact of calcium and phosphate level fluctuations in patients treated with sevelamer hydrochloride on alphaCACS.

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