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Updated: Aug 16, 2026
Percutaneous Contrast Echocardiography-guided Intramyocardial Injection and Cell Delivery in a Large Preclinical Model
Published on: January 21, 2018
[Primary percutanous intervention in acute mycardial infarction. A comparison with the DANAMI-2 results]
Samir M Ali Aljabbari1, Jan Kyst Madsen, Henning Kelbaek
1HS Rigshospitalet, Hjertecentret, Kardiologisk Laboratorium .
Insights
Primary angioplasty (PCI) is effective for acute ST-elevation myocardial infarction (STEMI), showing good survival and low complication rates. These findings align with previous trials, confirming PCI
Area of Science:
- Cardiology
- Interventional Cardiology
- Acute Myocardial Infarction Management
Background:
- Primary percutaneous intervention (PCI) demonstrated superior outcomes compared to thrombolysis in acute ST-elevation myocardial infarction (STEMI) treatment, as evidenced by trials like DANAMI-2.
- Key benefits include improved survival rates, reduced reinfarction incidence, and fewer cerebrovascular events.
Purpose of the Study:
- To evaluate the implementation and outcomes of primary PCI as a standard treatment for STEMI patients.
- To compare the results of this real-world implementation with those reported in the DANAMI-2 trial.
Main Methods:
- A prospective analysis was conducted on 212 patients admitted with STEMI between April and December 2002.
- Patients underwent acute coronary angiography, with primary PCI performed as indicated.
Main Results:
- At 30 days post-intervention, the observed mortality rate was 6.6%.
- Reinfarction and disabling stroke rates were both low, at 1.4% each.
- The combined endpoint incidence was 8%, consistent with DANAMI-2 findings.
Conclusions:
- Primary PCI is feasible and effective in routine clinical practice for STEMI management, adhering to established protocols.
- The study outcomes corroborate findings from the DANAMI-2 trial and recent meta-analyses, supporting the widespread adoption of primary PCI.
Introduction:
Several studies, including the DANAMI-2 trial, have shown that primary percutanous intervention (PCI) results in better survival, fewer reinfarctions and fewer cerebrovascular incidents than thrombolysis in the treatment of acute ST-elevation myocardial infarction (STEMI). The aim of this study was to follow the implementation of primary PCI as a routine treatment for patients with STEMI and to compare the results with those of DANAMI-2.
Materials And Methods:
We performed a prospective analysis of 212 patients admitted to our department from 1 April 2002 to 31 December 2002 with STEMI. Acute coronary angiography and, if indicated, primary PCI were performed.
Results:
At 30 days, the mortality rate was 6.6%, the reinfarction rate 1.4% and the rate of disabling stroke 1.4%. Combined endpoints were present in 8% of the patients. The results are in agreement with those from the DANAMI-2 trial.
Discussion:
Primary PCI can be performed in daily clinical practice in accordance with the DANAMI-2 protocol. The results are in agreement with data from newly published meta-analyses.
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