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Updated: Aug 16, 2026

Minimally Invasive Muscle Embedding (MIME) - A Novel Experimental Technique to Facilitate Donor-Cell-Mediated Myogenesis
Published on: August 24, 2017
IGF-1, inflammation and stem cells: interactions during muscle regeneration
Foteini Mourkioti1, Nadia Rosenthal
1EMBL Mouse Biology Unit Campus A. Buzzati-Traverso, via Ramarini 32, 00016 Monterotondo-Scalo (RM), Italy.
Abstract:
Insulin-like growth factor-I (IGF-1) is an important mediator in numerous developmental processes, such as proliferation, differentiation, survival, growth, apoptosis and regeneration. Mouse genetics have provided important insights into the signalling mechanisms that are necessary for the coordination of muscle repair. Recent studies on the role of IGF-1 in the promotion of cell recruitment to the injured muscle and the subsequent resolution of the inflammatory response have unveiled new perspectives into local repair mechanisms.
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