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Related Experiment Videos

Anticoagulant effects of sulphonated polyurethanes.

J H Silver1, A P Hart, E C Williams

  • 1Department of Chemical Engineering, University of Wisconsin-Madison 53706.

Biomaterials
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

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Water-soluble polyurethanes were studied for their impact on blood clotting. These polymers effectively delay thrombus formation through multiple interactions within the plasma coagulation cascade.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Hemostasis and Thrombosis Research

Background:

  • Sulfonated polyurethanes demonstrate favorable hemocompatibility.
  • Water-soluble polyurethanes represent a novel class for biomedical applications.
  • Understanding polymer-blood interactions is crucial for preventing thrombotic events.

Purpose of the Study:

  • To investigate the influence of water-soluble polyurethanes on thrombus formation.
  • To elucidate the mechanisms by which these polymers affect blood coagulation.

Main Methods:

  • Evaluation of clotting times in the presence of water-soluble polyurethanes.
  • Analysis of polymer interactions with key coagulation factors, including thrombin and fibrinogen.
  • Assessment of interference with fibrin polymerization processes.

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Main Results:

  • Water-soluble polyurethanes significantly delayed blood clotting times.
  • Mechanisms identified include direct complexation with thrombin.
  • Interference with fibrin polymerization and complex interactions involving plasma antiproteases were also observed.

Conclusions:

  • Water-soluble polyurethanes exhibit antithrombotic properties.
  • These polymers offer a promising avenue for developing improved blood-contacting medical devices.
  • The observed effects are mediated by multiple interactions within the coagulation system.