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Updated: Aug 16, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Qualification of arterial stiffness as a risk factor to the progression of chronic kidney diseases

Tsuneo Takenaka1, Taku Mimura, Yoshihiko Kanno

  • 1Department of Nephrology, Saitama Medical College, 38 Moro-hongo Moroyama, Iruma Saitama 350-0495, Japan.

American Journal of Nephrology
|August 20, 2005
PubMed

Insights

Augmentation index (AI), a measure of arterial stiffness, is linked to worsening non-diabetic chronic kidney disease (CKD) and left ventricular hypertrophy. Higher AI indicates increased risk for CKD progression.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Biomedical Engineering

Background:

  • Arterial stiffness, assessed by augmentation index (AI), may impact chronic kidney disease (CKD) progression.
  • The specific relationship between AI and non-diabetic CKD progression requires further characterization.

Purpose of the Study:

  • To investigate the association between augmentation index (AI) and the progression of non-diabetic chronic kidney diseases (CKDs).
  • To explore the role of AI in the development of left ventricular hypertrophy in patients with non-diabetic CKD.

Main Methods:

  • Pulse wave analysis was used to determine AI in 99 patients with non-diabetic CKDs.
  • Echocardiography was performed in 51 patients to assess left ventricular mass index.
  • Creatinine clearance was measured repeatedly in 41 patients to monitor CKD progression.

Main Results:

  • AI positively correlated with age and weight, and negatively with height and heart rate (R(2) = 0.50).
  • Elevated AI was associated with increased left ventricular mass index in male patients under angiotensin inhibition (r = 0.33, p < 0.05).
  • Higher baseline AI predicted a greater annual decrease in creatinine clearance in patients on angiotensin inhibition (r = -0.52, p < 0.01).

Conclusions:

  • Augmentation index (AI) and angiotensin contribute to left ventricular hypertrophy.
  • AI is identified as a risk factor for the progression of non-diabetic CKDs, independent of angiotensin.
  • These findings highlight AI as a potential therapeutic target in managing non-diabetic CKD.
Abstract

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