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Updated: May 5, 2026

Organ Culture and Whole Mount Immunofluorescence Staining of Mouse Wolffian Ducts
Published on: January 13, 2017
Wilms' tumour: connecting tumorigenesis and organ development in the kidney
Miguel N Rivera1, Daniel A Haber
1Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, Massachusetts 02129, USA. mnrivera@partners.org
Abstract:
Wilms' tumour, or nephroblastoma, is a common childhood tumour that is intimately linked to early kidney development and is often associated with persistent embryonic renal tissue and other kidney abnormalities. WT1, the first gene found to be inactivated in Wilms' tumour, encodes a transcription factor that functions as both a tumour suppressor and a critical regulator of renal organogenesis. Our understanding of the roles of WT1 in tumour formation and organogenesis have advanced in parallel, providing a striking example of the intersection between tumour biology, cellular differentiation and normal organogenesis.
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