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[The choroid plexuses: a dynamic interface between the blood and the cerebrospinal fluid]
N Strazielle1, M Mutin, J F Ghersi-Egea
1Unité INSERM 433, Université Claude Bernard Lyon I, Faculté de médecine RTH Laennec, Rue Guillaume Paradin, 69372 Lyon, France. strazielle@lyon.inserm.fr
Morphologie : Bulletin De L'Association Des Anatomistes
|August 23, 2005
Summary
The choroid plexuses regulate brain microenvironment and homeostasis through specialized epithelial cells and cerebrospinal fluid secretion. They also play roles in neuroprotection and supplying bioactive peptides to the brain.
Area of Science:
- Neuroscience
- Developmental Biology
- Physiology
Context:
- The choroid plexuses are crucial interfaces controlling brain microenvironment.
- They develop early in brain development from distinct neural tube regions.
- These structures protrude into the brain's ventricular system.
Purpose:
- To review the anatomical and histological organization of choroidal tissue.
- To describe the mechanisms of cerebrospinal fluid secretion.
- To present evidence for choroid plexus roles in neuroprotection and peptide supply.
Summary:
- Choroid plexuses regulate brain homeostasis via epithelial cell properties and transport mechanisms.
- Cerebrospinal fluid secretion is a primary studied function.
- Evidence suggests involvement in neuroprotection and delivery of bioactive polypeptides.
Impact:
- Understanding choroid plexus function is key to brain homeostasis and disease.
- Highlights the role of these structures in neuroprotection.
- Provides insights into the transport of essential molecules to the brain.