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Updated: Aug 16, 2026

Microdissection and Whole Mount Scanning Electron Microscopy Visualization of Mouse Choroid Plexus
Published on: December 16, 2022
[The choroid plexuses: a dynamic interface between the blood and the cerebrospinal fluid]
N Strazielle1, M Mutin, J F Ghersi-Egea
1Unité INSERM 433, Université Claude Bernard Lyon I, Faculté de médecine RTH Laennec, Rue Guillaume Paradin, 69372 Lyon, France. strazielle@lyon.inserm.fr
Abstract:
The choroid plexuses form one of the interfaces that control the brain microenvironment by regulating the exchanges between the blood and the central nervous system. They appear early during brain development. Originating from four different areas of the neural tube, they protrude into the ventricular system of the brain. The choroidal mechanisms involved in the control of brain homeostasis include the structural properties of the epithelial cells that restrict diffusional processes, as well as specific exchange and secretion mechanisms. In addition to the anatomical and histological organization of the choroidal tissue, this review describes the mechanism of cerebrospinal fluid secretion which is the most studied function of the choroid plexus. Experimental evidence for an implication of the choroid plexuses in neuroprotective mechanisms and in the supply of biologically active polypeptides to the brain are also reviewed.
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