Stem cells and frontiers of therapeutic advances in cancer

Area of Science:

• Oncology
• Immunology
• Stem Cell Biology

Background:

• Cancer is characterized by uncontrolled abnormal cell proliferation, driven by diverse etiological factors.
• Immunological defense mechanisms offer a therapeutic avenue beyond traditional chemotherapy and radiotherapy.
• Cell therapy, or anti-cancer cytotherapy, harnesses immune cells to target cancer cells.

Purpose of the Study:

• To explore the potential of stem cells in cancer therapy.
• To highlight stem cells' dual role in providing cellular potential and enabling targeted gene therapy.
• To review current global efforts in applying stem cell therapy for hematological malignancies and solid tumors.

Main Methods:

• Review of recent studies on anti-cancer cytotherapy.
• Focus on various immune-competent cells, including natural killer (NK) cells, cytotoxic cells, and dendritic cells.
• Emphasis on the application and therapeutic potential of stem cells.

Main Results:

• Stem cells are crucial for cellular potential and serve as vehicles for targeted gene therapy.
• Therapeutic approaches using stem cells are being developed globally for both blood cancers and solid tumors.
• Adult stem cell corpuscular therapy is emerging as a safe and inspiring cancer treatment module.

Conclusions:

• Immunotherapy, particularly cell therapy utilizing various immune cells and stem cells, presents a viable strategy against cancer.
• Stem cells play a pivotal role in advancing cancer treatment, offering both intrinsic therapeutic benefits and gene therapy applications.
• Adult stem cell corpuscular therapy demonstrates significant promise as a safe and effective anti-cancer modality.