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Related Experiment Videos

Staphylococcus aureus: Staphylokinase.

Maria I Bokarewa1, Tao Jin, Andrej Tarkowski

  • 1Department of Rheumatology and Inflammation Research, Sahlgrenska University Hospital, Guldhedsgatan 10, SE-41346 Göteborg, Sweden. martia.bokarewa@rheuma.gu.se

The International Journal of Biochemistry & Cell Biology
|August 23, 2005
PubMed
Summary
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Staphylokinase, a protein from Staphylococcus aureus, helps bacteria resist immune defenses and colonize tissues. Its expression is higher in skin infections, aiding bacterial survival and spread.

Area of Science:

  • Microbiology
  • Immunology
  • Bacteriology

Background:

  • Staphylokinase is a bacteriophage-encoded protein in Staphylococcus aureus.
  • It interacts with host proteins alpha-defensins and plasminogen.
  • Alpha-defensins are neutrophil-derived bactericidal peptides.

Purpose of the Study:

  • To investigate the role of staphylokinase in Staphylococcus aureus infections.
  • To understand staphylokinase's contribution to bacterial resistance and colonization.

Main Methods:

  • Analysis of staphylokinase interactions with alpha-defensins and plasminogen.
  • Expression level analysis in clinical isolates from different infection sites.
  • In vivo sepsis studies using isogenic Staphylococcus aureus strains.

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Main Results:

  • Staphylokinase binding to alpha-defensins neutralizes their bactericidal activity.
  • Staphylokinase-plasminogen complex activates plasmin, aiding tissue penetration.
  • High staphylokinase expression observed in skin/mucosal isolates, low in invasive isolates.
  • Absence of staphylokinase increased bacterial load in sepsis models.

Conclusions:

  • Staphylokinase is crucial for Staphylococcus aureus resistance to innate immunity.
  • It facilitates bacterial tissue penetration and colonization.
  • Staphylokinase acts as a significant colonization factor, promoting host-bacterial symbiosis.