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Updated: Aug 16, 2026
Longitudinal Two-Photon Imaging of Dorsal Hippocampal CA1 in Live Mice
Published on: June 19, 2019
Molarless-induced changes of spines in hippocampal region of SAMP8 mice
Kin-Ya Kubo1, Fumihiko Iwaku, Kazuko Watanabe
1Department of Oral Anatomy, Division of Oral Structure, Function and Development, Asahi University School of Dentistry, 1851 Hozumi, Mizuho, Gifu 501-0296, Japan. kubo@dent.asahi-u.ac.jp
Abstract:
We examined the effect of the molarless condition on the dendritic spines of hippocampal pyramidal cells in SAMP8 mice in comparison to its effect on learning ability in a maze test. The molarless condition caused a decrease in the number of the spines of CA1 pyramidal cells only in the aged mice showing a reduced learning ability. The results suggest the involvement of the molarless condition in an attenuation of input activities in the hippocampal synapses.
