Neuroendocrine and behavioral development during puberty: a tale of two axes

Puberty is marked by dramatic changes in neuroendocrine function. These changes have profound effects on the structure and function of the maturing nervous system, resulting in altered physiological and behavioral potentials in the adult organism. Indeed, the changes in neurobehavioral development during puberty rival those occurring during neonatal development. This review discusses the pubertal maturation of the hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal axes; specifically, how the pubertal rise in gonadal hormones influences the development of various steroid-dependent motivated behaviors in adulthood, as well as the differences in stress reactivity in prepubertal and adult animals. We conclude that puberty represents another significant and perhaps critical period of neurobehavioral development. Furthermore, we suggest that perturbations of the developing nervous system during this period of maturation may result in deleterious outcomes in the future physiological and behavioral function of an individual on reaching adulthood.