Related Experiment Video
Updated: Aug 16, 2026

Restraint to Induce Stress in Mice and Rats
Published on: December 6, 2024
MAO A knockout attenuates adrenocortical response to various kinds of stress
Nina K Popova1, Larissa N Maslova, Ekaterina A Morosova
1Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Pr. Lavrentieva#10, Novosibirsk 630090, Russia. npopova@bionet.nsc.ru
Abstract:
The effect of a lack of the gene encoding monoamine oxidase A (MAO A) in transgenic Tg 8 mice on the corticosterone response to restraint, cold, water deprivation-induced, or social acute stress as well as chronic variable stress was studied. It was found that Tg 8 mice with genetic MAO A knockout and wild-type C3H/HeJ (C3H) strain showed similar plasma corticosterone resting level. MAO A knockout mice differed from C3H mice by attenuated response to restraint (60 min), cold (4 degrees C, 60 min), and water deprivation (48 h) as well as to a chronic (15 days) variable stress. No difference between Tg 8 and C3H strains in the response to psychosocial stress (encounters for 30 min of six previously isolated mice) has been found. ACTH administration to dexamethasone-pretreated mice produced a similar corticosterone effect in Tg 8 and C3H mice, indicating that the decreased stress response in MAO A-deficient mice was due rather to the central mechanisms regulating stress-induced ACTH release than to adrenocortical responsiveness to ACTH.
Related Concept Videos
Physiological Foundation of Stress
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Psychological Responses to Stress
Stress Response System
Alarm stage
In the alarm stage, the body's initial...
Introduction to Stress and Lifestyle
Anatomy of the Adrenal Glands
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct regions...
Components of Stress
Interestingly, the hidden cube faces also experience these stresses, equal and opposite to those on the...

